如何计算3组或更多组之间的SMD？

我有兴趣通过一个分层变量计算成对标准化平均差（SMD）。通常这是在两组之间计算，但是我们可以在 3 组或更多组中进行计算吗？

附：我是 gtsummary 包的忠实粉丝，所以我尝试使用以下方法进行此分析示例 2 来自这个令人惊奇的包 http://www.danieldsjoberg.com/gtsummary/reference/add_difference.html如下：

library(tidyverse)
library(gtsummary)
#> #BlackLivesMatter
add_difference_ex2 <-
  trial %>%
  mutate(trt=ifelse(age<40,"Drug C", trt)) %>% 
  select(trt, age, marker, grade, stage) %>%
  tbl_summary(
    by = trt,
    statistic = list(all_continuous() ~ "{mean} ({sd})"),
    missing = "no",
    include = c(age, marker, trt)
  ) %>%
  add_n() %>%
  add_difference(adj.vars = c(grade, stage))
#> 11 observations missing `trt` have been removed. To include these observations, use `forcats::fct_explicit_na()` on `trt` column before passing to `tbl_summary()`.
#> Error: 'tbl_summary'/'tbl_svysummary' object must have a `by=` value with exactly two levels

^{Created on 2021-10-27 by the reprex package https://reprex.tidyverse.org (v2.0.1)}

要添加成对标准化均差 (SMD)，您首先需要定义一个函数来计算并返回成对 SMD 估计值。完成此操作后，您可以使用通用函数将其添加到 gtsummary 表中add_stat()。下面的例子！

library(gtsummary)
library(tidyverse)

# function to calculate pairwise smd
pairwise_smd <- function(data, variable, by, ...) {
  data <- 
    dplyr::select(data, all_of(c(variable, by))) %>%
    rlang::set_names(c("variable", "by")) %>%
    dplyr::filter(complete.cases(.)) %>%
    arrange(desc(.data$by))
  
  tibble(exclude = unique(data$by)) %>%
    mutate(
      include = map_chr(.data$exclude, ~unique(data$by) %>% setdiff(.x) %>% paste(collapse = " vs. ")),
      data_subset = 
        map(
          .data$exclude, 
          ~data %>%
            filter(!.data$by  %in% .x) %>%
            mutate(by = factor(.data$by))
        ),
      smd = map_dbl(.data$data_subset, ~smd::smd(.x$variable, .x$by)$estimate)
    ) %>%
    select(include, smd) %>%
    spread(include, smd)
}

tbl <-
  trial %>%
  select(age, grade, stage) %>%
  tbl_summary(
    by = grade,
    statistic = list(all_continuous() ~ "{mean} ({sd})"),
    missing = "no"
  ) %>%
  add_stat(fns = everything() ~ pairwise_smd)

^{Created on 2021-10-27 by the reprex package https://reprex.tidyverse.org (v2.0.1)}