你的问题虽然不那么明显，但相当平庸。问题不在于tinker or pythonnet，它源于COM线程模型。
首先，由于您正在使用clr，让我们尝试直接使用对话框（并不是绝对需要导入tinker模块）：
# importing pythonnet
import clr
# adding reference (if necessary) to WinForms and importing dialogs
# clr.AddReference('System.Windows.Forms')
from System.Windows.Forms import OpenFileDialog, FolderBrowserDialog
# creating instances of dialogs
folder_dialog = FolderBrowserDialog()
file_dialog = OpenFileDialog()
# try to show any of them
folder_dialog.ShowDialog()
file_dialog.ShowDialog()
如您所见，它就像您的情况一样悬挂着。原因如上所述，源于线程的单元状态（[1] https://msdn.microsoft.com/en-us/library/ms809971.aspx, [2] https://msdn.microsoft.com/en-us/library/windows/desktop/ms693344(v=vs.85).aspx).
因此clrimplicilty 将此状态设置为 MTA（多线程单元），可以通过以下方式进行测试CoGetApartmentType https://msdn.microsoft.com/en-us/library/windows/desktop/dd542641%28v=vs.85%29.aspx功能：
# importing ctypes stuff
import ctypes
get_apartment = ctypes.windll.ole32.CoGetApartmentType
# comment/uncomment this import to see the difference
# import clr
apt_type = ctypes.c_uint(0)
apt_qualifier = ctypes.c_uint(0)
if get_apartment(ctypes.byref(apt_type), ctypes.byref(apt_qualifier)) == 0:
# APPTYPE enum: https://msdn.microsoft.com/en-us/library/windows/desktop/ms693793(v=vs.85).aspx
# APTTYPEQUALIFIER enum: https://msdn.microsoft.com/en-us/library/windows/desktop/dd542638(v=vs.85).aspx
print('APTTYPE = %d\tAPTTYPEQUALIFIER = %d' % (apt_type.value, apt_qualifier.value))
else:
print('COM model not initialized!')
但是，许多较旧的 COM 对象（例如 shell 对话框）需要 STA 模式。
可以找到关于这两种状态之间差异的很好的解释here https://stackoverflow.com/questions/4154429/apartmentstate-for-dummies or there https://stackoverflow.com/questions/127188/could-you-explain-sta-and-mta.
最后给出解决方案：
1）使用STA线程进行对话：
# importing tkinter stuff
import tkinter as tk
from tkinter.filedialog import askdirectory, askopenfilename
# importing pythonnet
import clr
# adding reference (if necessary) to WinForms and importing dialogs
#clr.AddReference('System.Windows.Forms')
from System.Windows.Forms import OpenFileDialog, FolderBrowserDialog
# adding reference (if necessary) to Threading and importing Thread functionality
#clr.AddReference('System.Threading')
from System.Threading import Thread, ThreadStart, ApartmentState
# WinForms thread function example
def dialog_thread():
folder_dialog = FolderBrowserDialog()
file_dialog = OpenFileDialog()
folder_dialog.ShowDialog()
file_dialog.ShowDialog()
# Tk thread function example
def tk_dialog_thread():
root = tk.Tk()
root.withdraw()
askdirectory()
askopenfilename()
# check again apartment state at start
current_state = Thread.CurrentThread.GetApartmentState()
if current_state == ApartmentState.STA:
print('Current state: STA')
elif current_state == ApartmentState.MTA:
print('Current state: MTA')
# start dialogs via CLR
thread = Thread(ThreadStart(dialog_thread))
thread.SetApartmentState(ApartmentState.STA)
thread.Start()
thread.Join()
# start dialogs via Tkinter
thread = Thread(ThreadStart(tk_dialog_thread))
thread.SetApartmentState(ApartmentState.STA)
thread.Start()
thread.Join()
2) 强制 STA 模式通过CoInitialize https://msdn.microsoft.com/en-us/library/windows/desktop/ms678543(v=vs.85).aspx/CoInitializeEx https://msdn.microsoft.com/en-us/library/windows/desktop/ms695279(v=vs.85).aspx在 CLR 为 MTA 执行此操作之前：
# importing ctypes stuff
import ctypes
co_initialize = ctypes.windll.ole32.CoInitialize
# importing tkinter stuff
import tkinter as tk
from tkinter.filedialog import askdirectory, askopenfilename
# Force STA mode
co_initialize(None)
# importing pythonnet
import clr
# dialogs test
root = tk.Tk()
root.withdraw()
askdirectory()
askopenfilename()
